Epidural clonidine employed being an adjunct to local anesthetics has three unique mechanisms of action. 1st, the stimulation of alpha-2-receptors during the dorsal horn reduces pain transmission. Secondly, clonidine could potentially cause area vasoconstriction that limits vascular removal of local epidural anesthetics. Discover the implications for future well being https://www.proleviate.com/post/the-new-pain-killer-conolidine