Melanoma frequently harbors genetic alterations in key molecules leading to the aberrant activation of PI3K and its downstream pathways. Although the role of PI3K/AKT/mTOR in melanoma progression and drug resistance is well documented. targeting the PI3K/AKT/mTOR pathway showed less efficiency in clinical trials than might have been expected. since the suppression of the PI3K/mTOR sig... https://www.chiggate.com/jerome-brown-philadelphia-eagles-mitchell-ness-1990-legacy-jersey-discount/