In this article, we present that conolidine, a all-natural analgesic alkaloid used in common Chinese drugs, targets ACKR3, thereby delivering extra evidence of a correlation concerning ACKR3 and discomfort modulation and opening different therapeutic avenues for the therapy of Persistent pain. Utilized in conventional Chinese, Ayurvedic, and Thai drugs. https://stephenr951tkc8.wikipublicist.com/user