Pentobarbital will reduce the extent or outcome of pioglitazone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unfamiliar. pentobarbital will decrease the extent or outcome of lopinavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. pentobarbital will lower the level or influence of dutasteride by impacting hepatic/intestinal... https://confuciusi666hsn5.wikipowell.com/user